The FDA approved a new table that combines Tylenol with naproxen, an anti-inflammatory medication. By combining two well-established pain medicines that work through different mechanisms, TYLENOL® with Naproxen was designed to provide powerful pain relief while using lower doses of each ingredient. Tylenol 3 is a prescription painkiller that combines acetaminophen with codeine. Learn its side effects, dosages, and risk of addiction and dependence. Discover how TYLENOL® pain relieving products & medicine can help you and your family feel better. Learn about symptoms, treatments, dosages and product info. TYLENOL® with Naproxen is a first-of-its-kind OTC combination that delivers fast-acting pain relief lasting 12 hours. Find patient medical information for Acetaminophen (Tylenol) on WebMD including its uses, side effects and safety, interactions, pictures, warnings, and user ratings Learn about the side effects of Tylenol (acetaminophen), from common to rare, for consumers and healthcare professionals. Overview: Acetaminophen/codeine is used to treat certain types of pain. It reduces pain signals and changes how your body feels pain. Common side effects include constipation and feeling sleepy. Yes, naproxen and acetaminophen (Tylenol) can be taken together safely for most healthy adults when used as directed, as they work differently to alleviate pain and have minimal direct interaction with each other. Acetaminophen is used to relieve pain and reduce fever in patients. It does not become habit-forming when taken for a long time. But acetaminophen may cause other unwanted effects when taken in large doses, including serious liver damage.